Clinical microdialysis in neuro-oncology: principles and applications

Clinical microdialysis in neuro-oncology: principles and applications

Clinical microdialysis allows a discrete volume of the brain to be sampled for neurochemical analysis of neurotransmitters, metabolites, biomarkers, and drugs. The technique can be safely used in humans intraoperatively, in the intensive care unit, and in ambulatory settings. Microdialysis probes, micropumps, and analytical equipment are commercially available and have been used extensively for...

Novel clinical trials in neuro-oncology

Clinical research within neuro-oncology is complicated by several factors, including complex tumor biology and a variable impact on patients, as a consequence both of disease location and degree of malignancy. Clinical studies are complicated by these factors as well as issues of determining optimal clinical end points. This review highlights relevant aspects of neurooncologic diseases, includi...

neuronavigation: principles, clinical applications and potential pitfalls.

localization of brain lesions and prevention of damage to vital structures are important in operation of brain pathologies. despite development of many techniques including angiography, mri, sonography, and frame base stereotaxy, a more accurate localizing technique is still needed (1, 2). a step forward to achieve this goal is to develop a navigation system. in this manuscript, we explained so...

Optical Biochemical Imaging: Potential New Applications in Neuro-Oncology

Imaging in neuro-oncology

Imaging plays several key roles in managing brain tumors, including diagnosis, prognosis, and treatment response assessment. Ongoing challenges remain as new therapies emerge and there are urgent needs to find accurate and clinically feasible methods to noninvasively evaluate brain tumors before and after treatment. This review aims to provide an overview of several advanced imaging modalities ...